Scientists from the US found that obesity has a negative effect on stem cells that produce blood. The results of the study were published in the Journal of Experimental Medicine.
By conducting experiments on mice, the researchers found that obesity creates a load on the so-called hematopoietic stem cells, or hemocytoblasts, located in the tissues of the red bone marrow inside the cavities of most bones.
The structure of cells in obese mice changed, which led to a decrease in their adaptability in the long term. However, even after scientists planted mice on a diet and returned their weight back to normal, part of the structural changes remained.
The authors suggest that these changes are associated with increased expression of the Gfi1 gene, which, in turn, causes oxidative stress of the body in obesity. According to scientists, in the future this discovery will help to find out how a person’s lifestyle, in particular, his nutrition, is related to the process of formation of blood cells and the development of blood cancer.