Scientists have found a barrier that inhibits cancer

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UNITED STATES (VOP TODAY NEWS) — A team of researchers from the Swiss Federal Institute of Technology is working on the destruction of cancer cells using the mechanism of apoptosis or programmed cell death.

The results of their research showed that activin B protein and ALK7 receptor create a signaling pathway that causes cancer cells to naturally kill themselves (apoptosis) and prevent the formation of tumors (oncogenesis), as well as their further spread (metastases).

In order for cancer blocking to work, the ALK7 receptor and activin B protein, which actually activates it, must work in tandem. Researchers have discovered that smart cancer “senses danger” and suppresses ALK7, activin B or even both in advance, and thus survives and grows.

Experiments on mice demonstrated that in cases where scientists did not allow cancer to suppress “threatening elements”, tumor development ceased. This method was able to stop neuroendocrine pancreatic cancer and breast cancer in mouse models.

Scientists also examined patients with various types of cancer and found a link between the presence of ALK7 and a lower likelihood of recurrence. Metastases also apparently did not form when higher levels of ALK7 were present, especially in the case of breast cancer.

Although most of the tests were performed on mice, scientists believe that we have enough biological and chemical similarities to fluffy rodents, especially when it comes to the development of cancer. So, the found “barrier” is a promising target for anticancer drugs of the future.


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