A cannabis pill administered to adults with epilepsy could reduce seizures, Australian researchers said on Wednesday.
The drug is the subject of a world-first clinical trial in Australia and New Zealand led by Melbourne researchers.
Terry O’Brien, a neurologist at the Royal Melbourne Hospital and head of the trial, said there was desperate need for a treatment for the 30 percent of epileptic sufferers who have a drug-resistant form of the neurological condition which causes seizures.
O’Brien said that the cannabis gel, which has had the hallucinogenic element of the plant removed, would be more effective at reducing the seizures than taking the drug orally.
“Cannabidiol (the non-psychoactive component of the cannabis) has a high first metabolism in the liver,” O’Brien told News Limited on Wednesday.
“It means we don’t know exactly how much of the drug is getting to the brain because much of it is metabolised in the liver and stomach before it even gets there, this is one of the reasons the recreational drug is inhaled, so it’s a great advantage to be able to bypass that problem.
“A lot of people with uncontrolled epilepsy are very keen to try cannabidiol and this is the first double-blind randomized control trial that has been available to adults in Australia and internationally.”
O’Brien, who is also the chairman of the Australian Epilepsy Clinical Trials Network who will run the trial on 180 patients, said patients had been “self-medicating” with recreational cannabis but the effect of other ingredients, such as the mind-altering tetrahydrocannabinol, on the brain is not known.
Grame Shears, CEO of The Epilepsy Foundation, said randomized trials of cannabis-derived drugs were important to establish if the reported benefits were a placebo effect.
“A cannabis product is just like any other medication, except that it is derived from a natural source, so we need to do the same randomized control trials to get evidence of its impact,” she said.
Approximately 500,000 Australians suffer from epilepsy.
– Cannabis Recipes: Make Your Own THC Pills in 5 Easy Steps –
We all know smoking is bad right? If you don’t want to smoke and are looking for another way to get high without any of the harmful effects associated with smoking, or you need a way to get high and smoking isn’t a viable option (e.g. large events, public places, concerts etc) then why don’t you try out these home-made THC pills? They are ridiculously easy to make…
The concept is simple – it’s a capsule filled with a mixture containing THC that’s ready to be absorbed into your system. The dose is easy to control as well.
2.Cannabis (your chosen amount)
3.Something that will grind up the cannabis
4.Heat source e.g. Stove
5.Bowl (something to mix/grind the cannabis and oil in)
6.Pill Capsules (empty some vitamin capsules out)
Dosage: Each dose will be one capsule. You can work out dosage if you know the rough % of thc in the flower/hash/extract you are using. If your herb has 10% THC then 1g will be 100mg. Good herb will have 20-25% THC on average so take this into account if using potent strains! As a rough guide try making 5 capsules out of one gram of cannabis. Non-experienced cannabis users can half this dose.
Put your finely ground herbs onto baking paper and place in the oven for 45-60mins. This is to decarboxylate the cannabis and make the THC ready for consumption. Once it’s out the oven, add just enough oil to saturate it, then grind this for about a minute. Heat up a pan on the stove and transfer the mixture
You’re going to want to heat up for 15 minutes, grinding it into a paste and stirring, not letting it get too hot.
Let the mixture cool down
Use the small spoon to transfer the mixture into the capsules. You could filter the mixture, but there’s no need when you’re going to swallow the capsules, so you’re good to go! Store them in the freezer.
This method of consumption is ideal for when you cannot smoke. Remember that the way THC acts on your system when ingested is different to when smoked – it will take longer to hit you, and it may be more intense and last longer.
– Are Time-Released Cannabis Pills the Future of Medical Marijuana? –
Wana Brands, an edibles manufacturing company based in Boulder, Colorado, has created a line of cannabis capsules they’ve dubbed “Wana Caps” that could be big for medical marijuana patients. The goal was to offer an alternative consumption method to patients other than smoking or consuming edibles. So what’s different about these capsules compared to other pill forms of concentrated cannabis?
According to Wana Brands owner John Whiteman, Wana has teamed up with Cannabics, an Israeli pharmaceutical company, to create the industry’s first extended release formula that will deliver measured doses over a time frame of up to 12 hours. Each capsule contains two doses, one that activates shortly after ingestion and a second one that activates about four hours later.
Time-released capsules can bridge the comfort gap for patients who are curious about trying medical marijuana to help relieve their symptoms but are intimidated by/not knowledgeable about the more common consumption methods. This form mirrors that of prescription drugs, of which medical patients are all-too familiar ingesting on a regular basis. And the metered dosing offers convenience for patients who need long-term relief, portability, and discretion.
This product could be huge for the cannabis movement, as it would be an easy-to-manage consumption method for novice medical marijuana patients. What’s your take? Would you switch from your preferred consumption method to time-release cannabis capsules? Weigh in below:
As a medical marijuana patient, what is (or would be) your preferred consumption method? (Choose all that apply)
Vote here: https://www.leafly.com
– What is a Seizure? –
- A seizure is a sudden surge of electrical activity in the brain.
- A seizure usually affects how a person appears or acts for a short time.
- Many different things can occur during a seizure. Whatever the brain and body can do normally can also occur during a seizure
What happens in the brain during a seizure?
- The electrical activity is caused by complex chemical changes that occur in nerve cells.
- Brain cells either excite or inhibit (stop) other brain cells from sending messages. Usually there is a balance of cells that excite and those that can stop these messages. However, when a seizure occurs, there may be too much or too little activity, causing an imbalance between exciting and stopping activity. The chemical changes can lead to surges of electrical activity that cause seizures.
- Seizures are not a disease in themselves. Instead, they are a symptom of many different disorders that can affect the brain. Some seizures can hardly be noticed, while others are totally disabling.
The nature of seizures varies, because the lobes of the brain control different behaviors, movements and experiences.
If I have just one or two seizures does that mean I will get epilepsy?
- About half of the people who have one seizure without a clear cause will have another one, usually within 6 months.
- If there is a known cause for your seizure (for example, brain injury or other type of known brain condition), then you are twice as likely to have another seizure.
- If you have two seizures, there’s about an 80% chance that you’ll have more.
- If your first seizure occurred at the time of an injury or infection in the brain, then you are more likely to develop epilepsy. Often, more seizures don’t occur until weeks or months after the initial injury or infection.
- More seizures are also likely if your doctor finds abnormalities on a neurological examination (tests that are done in a doctor’s office to see how the nervous system is working).
- An EEG test or electroencephalogram (e-LEK-tro_en_SEF-uh_LOG-ram) can look at the electrical activity of the brain and may help predict whether more seizures will occur. Certain patterns on the EEG are typical of epilepsy. If your brain waves show patterns of that type, you are about twice as likely to develop epilepsy.
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(Different agencies we mention above contributed for this report “Cannabis pill administered to adults with epilepsy could reduce seizures, researchers”, edited to fit the style of the page, added additional material and illustrations by Alad Von Alad via VOP)